Brilliant Article about the Benefits of Omega-3 Fatty Acids
February 7, 2014
I just read this brilliant article on www.empowereddoctor.com about the benefits of Omega-3 fatty acids...
Omega-3 fatty acids demonstrate the capacity to slow the growth of triple-negative breast cancer cells when compared to cells from luminal types of cancer. This is according to research from Fox Chase Cancer Center.
The study researchers explained that omega-3 fatty acids are capable of slowing all cancerous cell types, but were observed to be much more impactful against triple-negative cell lines. These cells saw their proliferation rate drop by as much as 90%.
Tuna, sardines, salmon (oily fish), hemp and flax are examples of foods with an abundance of omega-3s. Prior research has found these compounds have benefits in disrupting crucial functions in cancer cells, specifically those relating to programmed cell death (apoptosis) and growth.
Study author, Thomas Pogash explains that this new discovery highlights the essential role compounds commonly found in our foods can play in warding off cancer. Compared to a western diet, the Mediterranean diet, which has more omega-3s, leads to a lower cancer rate.
It’s simply because the diet contains more fish.
Breast cancers are not all the same; they differ at molecular levels. That is why patients do not all respond the same to treatments. In the case of triple-negative tumors, there is a lack of receptors for estrogen, progesterone, and HER2 (a protein). For patients with this form of breast cancer, treatments using tamoxifen, which targets estrogen receptors, and trastuzumab, which blocks the HER2 receptors, do not work.According to Dr.
Jose Russo, there are currently no targeted therapies for women with triple-negative breast cancer. Standard care for early stage disease involves the use of combination chemotherapies. He adds that this type of cancer, more frequently found among Latina and African-American women, is a highly aggressive form of the disease with a low survival rate. There is no specific treatment to combat it.
When a cancer cell processes omega-3 fatty acids, they are digested into metabolites. The research team sought to understand what impact large omega-3 parent molecules, as well as their metabolic derivatives, on three luminal cell lines and seven basal-type triple negative cell lines.
The researchers discovered that omega-3 and its metabolites are capable of slowing growth in all cancer cell lines. However, they observed that they were considerably more effective in undermining proliferation in triple-negative cell lines. The researchers also discovered that the omega-3 metabolites lowered the movement of basal cell lines by 20% to 60%.